SHB (gene)

Src homology 2 domain containing adaptor protein B

Identifiers

SHB; RP11-3J10.8; bA3J10.2

External IDs

OMIM: 600314 MGI: 98294 HomoloGene: 74458 GeneCards: SHB Gene

Gene Ontology
Molecular function	• SH3/SH2 adaptor activity
Cellular component	• cytoplasm • plasma membrane
Biological process	• angiogenesis • apoptosis • signal transduction • multicellular organismal development • cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
37.92 – 38.07 Mb

Chr 4:
45.44 – 45.55 Mb

PubMed search

[1]

[2]

SH2 domain-containing adapter protein B is a protein that in humans is encoded by the SHB gene.^[1]^[2]

Interactions

SHB (gene) has been shown to interact with Fibroblast growth factor receptor 1,^[3] Src,^[3] Linker of activated T cells,^[4]^[5] Lymphocyte cytosolic protein 2,^[5] ZAP-70,^[5] EPS8,^[3] PIK3R1^[3] and VAV1.^[5]

References

^ Yulug IG, Hillermann R, Fisher EM (May 1995). "The SHB adaptor protein maps to human chromosome 9". Genomics 24 (3): 615–7. doi:10.1006/geno.1994.1681. PMID 7713524.
^ "Entrez Gene: SHB Src homology 2 domain containing adaptor protein B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6461.
^ ^a ^b ^c ^d Karlsson, T; Songyang Z, Landgren E, Lavergne C, Di Fiore P P, Anafi M, Pawson T, Cantley L C, Claesson-Welsh L, Welsh M (Apr. 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene (ENGLAND) 10 (8): 1475–83. ISSN 0950-9232. PMID 7537362.
^ Lindholm, C K; Gylfe E, Zhang W, Samelson L E, Welsh M (Sep. 1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells". J. Biol. Chem. (UNITED STATES) 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. ISSN 0021-9258. PMID 10488157.
^ ^a ^b ^c ^d Lindholm, Cecilia K; Henriksson Maria L, Hallberg Bengt, Welsh Michael (Jul. 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". Eur. J. Biochem. (Germany) 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. ISSN 0014-2956. PMID 12084069.

Karlsson T, Songyang Z, Landgren E et al. (1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene 10 (8): 1475–83. PMID 7537362.
Welsh M, Mares J, Karlsson T et al. (1994). "Shb is a ubiquitously expressed Src homology 2 protein". Oncogene 9 (1): 19–27. PMID 8302579.
Karlsson T, Welsh M (1996). "Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb". Oncogene 13 (5): 955–61. PMID 8806685.
Welsh M, Songyang Z, Frantz JD et al. (1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins". Oncogene 16 (7): 891–901. doi:10.1038/sj.onc.1201607. PMID 9484780.
Karlsson T, Kullander K, Welsh M (1998). "The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells". Cell Growth Differ. 9 (9): 757–66. PMID 9751119.
Lindholm CK, Gylfe E, Zhang W et al. (1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells". J. Biol. Chem. 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. PMID 10488157.
Dixelius J, Larsson H, Sasaki T et al. (2000). "Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis". Blood 95 (11): 3403–11. PMID 10828022.
Hooshmand-Rad R, Lu L, Heldin CH et al. (2000). "Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization". Exp. Cell Res. 257 (2): 245–54. doi:10.1006/excr.2000.4896. PMID 10837138.
Lu L, Annerén C, Reedquist KA et al. (2000). "NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway". Exp. Cell Res. 259 (2): 370–7. doi:10.1006/excr.2000.4984. PMID 10964504.
Diakonova M, Gunter DR, Herrington J, Carter-Su C (2002). "SH2-Bbeta is a Rac-binding protein that regulates cell motility". J. Biol. Chem. 277 (12): 10669–77. doi:10.1074/jbc.M111138200. PMID 11786545.
Lindholm CK, Henriksson ML, Hallberg B, Welsh M (2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". Eur. J. Biochem. 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.
Cross MJ, Lu L, Magnusson P et al. (2003). "The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells". Mol. Biol. Cell 13 (8): 2881–93. doi:10.1091/mbc.E02-02-0103. PMC 117949. PMID 12181353. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=117949.
Lindholm CK (2002). "IL-2 receptor signaling through the Shb adapter protein in T and NK cells". Biochem. Biophys. Res. Commun. 296 (4): 929–36. doi:10.1016/S0006-291X(02)02016-8. PMID 12200137.
Holmqvist K, Cross M, Riley D, Welsh M (2003). "The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells". Cell. Signal. 15 (2): 171–9. doi:10.1016/S0898-6568(02)00076-1. PMID 12464388.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Welsh N, Makeeva N, Welsh M (2003). "Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins". Mol. Med. 8 (11): 695–704. PMC 2039954. PMID 12520086. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2039954.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Holmqvist K, Cross MJ, Rolny C et al. (2004). "The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration". J. Biol. Chem. 279 (21): 22267–75. doi:10.1074/jbc.M312729200. PMID 15026417.
Humphray SJ, Oliver K, Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081.

SHB (gene)

Interactions

References

Further reading